55 תאורי מקרה המדווחים על תופעות לוואי קשות לחיסוני הפפילומה

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למרות שאין לאף חוקר אינטרס כלכלי לדווח על פגיעות שנגרמו מחיסון הפפילומה, התפרסמו בספרות המדעית במהלך השנים האחרונות דיווחים על מקרי פגיעה קשים בעקבות החיסון.

מרבית התופעות המדווחות הן אוטואימוניות, מה שלא ממש מפתיע לנוכח העובדה שחיסוני הפפילומה כוללים אדג'ובנט חזק במיוחד.

להלן רשימה של 55 תאורי מקרה המדווחים על תופעות כמו זאבת, כשל שחלתי, ADEM, ITP, איבוד ראיה, ועוד.

לקריאת הפוסט המלא על חיסון הפפילומה – האם הוא בטוח ויעיל – ליחצו כאן.

1. 

Demyelinating disease and vaccination of the human papillomavirus. Álvarez-Soria MJ, Hernández-González A, Carrasco-García de León S, del Real-Francia MÁ, Gallardo-Alcañiz MJ, López-Gómez JL. 

Rev Neurol, 2011, 52, 472. 

http://www.ncbi.nlm.nih.gov/pubmed/21425100

2. 

Demyelinating disease and polyvalent human papilloma virus vaccination. Chang J, Campagnolo D, Vollmer TL, Bomprezzi R. 

J Neurol-Neurosurg Psychiatry, 2010, 1-3.

http://jnnp.bmj.com/content/early/2010/10/08/jnnp.2010.214924.extract

3. 

Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune/inflammatory syndrome induced by adjuvants. Colafrancesco S, Perricone C, Tomljenovic L, Shoenfeld Y. Am. 

J Reprod Immunol, 2013, 70, 309. 

http://www.ncbi.nlm.nih.gov/pubmed/23902317

4. 

Pancreatitis following human papillomavirus vaccination. Das A, Chang D, Biankin AV, Merrett ND. 

Med J Aust, 2008, 189, 178.

http://www.ncbi.nlm.nih.gov/pubmed/18673112

5.

Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old girl. Della Corte C, Carlucci A, Francalanci P, Alisi A, Nobili V.

Vaccine, 2011, 29, 4654. 

http://www.ncbi.nlm.nih.gov/pubmed/21596082

6. 

A 16-Year-Old Girl With Bilateral Visual Loss and Left Hemiparesis Following an Immunization Against Human Papilloma Virus. DiMari J Jr, Hajjar M, Ciesielski T. 

J Child Neurol, 2010, 25, 321. 

http://www.ncbi.nlm.nih.gov/pubmed/20189933

7. 

Human papillomavirus vaccine and systemic lupus erythematosus, Gatto M, Agmon-Levin N, Soriano A, Manna R, Maoz-Segal R, Kivity S, Doria A, Shoenfeld Y. 

Clinical Rheumatology, 2013, 32, 1301.

http://www.ncbi.nlm.nih.gov/pubmed/23624585

8. 

Premature ovarian failure 3 years after menarche in a 16-year-old girl following human papillomavirus vaccination. 

Little DT, Ward HRG. 

BMJ Case Rep, 2012, bcr2012006879.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543769/

9. 

Vasculitis following HPV immunization. Melo Gomes S, Glover M, Malone M, Brogan P. 

Rheumatology, 2013, 52, 581.

http://rheumatology.oxfordjournals.org/content/52/3/581.long

10. 

Acute disseminated encephalomyelitis with tumefactive lesions after vaccination against human papillomavirus. Mendoza Plasencia Z, Gonzalez Lopez M, Fernandez Sanfi el ML, Muniz Montes JR. 

Neurologia, 2010, 25, 58.  

http://www.ncbi.nlm.nih.gov/pubmed/20388462

11. 

Bilateral Papilledema Following Human Papillomavirus Vaccination. Marco Rossia, Chiara Bettini, Caterina Paganoc. 

J Med Cases, 2011, 2, 222.

http://www.journalmc.org/index.php/JMC/article/view/256

12. 

Immune thrombocytopenic purpura following human papillomavirus vaccination. Pugnet G, Ysebaert L, Bagheri H, Montastruc JL, Laurent G. 

Vaccine, 2009, 27, 3690.

http://www.ncbi.nlm.nih.gov/pubmed/19464550

13.

?HPV vaccine: a cornerstone of female health a possible cause of ADEM.

V. Schaffer, S. Wimmer, I. Rotaru, R.Topakian, H . P. Haring, F. T. Aichner. 

J Neurol 2008, 255, 1818.

http://link.springer.com/article/10.1007%2Fs00415-008-0867-x#page-1

14. 

CNS demyelination and quadrivalent HPV vaccination. Sutton I, Lahoria R, Tan I, Clouston P, Barnett M.  

Mult Scler. 2009, 15, 116.

http://www.ncbi.nlm.nih.gov/pubmed/18805844

15. 

Acute disseminated encephalomyelitis following vaccination

against human papilloma virus. Wildemann B, Jarius S, Hartmann M, Regula JU, Hametner C. 

Neurology, 2009, 72, 2132.

http://www.neurology.org/content/72/24/2132.extract

16.

Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants”: Case Report and Literature Review. 

Tomljenovic L, Colafrancesco S, Perricone C, Shoenfeld Y.

Journal of Investigative Medicine High Impact Case Reports, 2014, 2(1), 1.

http://hic.sagepub.com/content/2/1/2324709614527812.full#ref-12

17.

Postural tachycardia syndrome following human papillomavirus vaccination.

S. Blitshteyn. 

European Journal of Neurology, 2014, 21, 135

http://www.ncbi.nlm.nih.gov/pubmed/24102827

18.

Peripheral sympathetic nerve dysfunction in adolescent Japanese girls following immunization with the human papillomavirus vaccine.

Kinoshita T, Abe RT, Hineno A, Tsunekawa K, Nakane S, Ikeda S.

Intern Med, 2014, 53(19), 2185.

http://www.ncbi.nlm.nih.gov/pubmed/25274229.

19.

Suspected side effects to the quadrivalent human papilloma vaccine.

Brinth L, Theibel AC, Pors K, Mehlsen J.

Dan Med J, 2015, 62(4), A5064.

http://www.danmedj.dk/portal/page/portal/danmedj.dk/dmj_forside/PAST_ISSUE/2015/DMJ_2015_04/A5064

20.

Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old .girl

.Della Corte Ca, Carlucci A, Francalanci P, Alisi A, Nobili V

.Vaccine, 2011, 29, 4654

http://www.ncbi.nlm.nih.gov/pubmed/21596082

21.  

Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination A Case Series Seen in General Practice. Little DT, Ward HRG.

Journal of Investigative Medicine High Impact Case Reports, 2014, 2(4), 1.

http://hic.sagepub.com/content/2/4/2324709614556129.full

22.

Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine.

Anaya JM, Reyes B, Perdomo-Arciniegas AM, Camacho-Rodríguez B, Rojas-Villarraga A.

Clin Exp Rheumatol, 2015, 33(4), 545

http://www.ncbi.nlm.nih.gov/pubmed/25962455

23.

Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report.

Yonee C, Toyoshima M, Maegaki Y, Kodama Y, Hayami H, Takahashi Y, Kusunoki S, Uchibori A, Chiba A, Kawano Y.

Neuropediatrics, 2013, 44(5), 265.

http://www.ncbi.nlm.nih.gov/pubmed/23378179

24.

Death after Quadrivalent Human Papillomavirus (HPV) Vaccination:  Causal or Coincidental?.

Lucija Tomljenovic, Christopher A Shaw 

http://dx.doi.org/10.4172/2167-7689.S12-001

25.

A catastrophic failure.

Wehbe E

http://dx.doi.org/10.1016/j.amjmed.2010.09.020

26.

Postural tachycardia syndrome after vaccination with Gardasil.

S. Blitshteyn

 European Journal of Neurology,  2010, 17, 7, 52 

http://dx.doi.org/10.1111/j.1468-1331.2010.03021.x

27.

Orthostatic intolerance and postural tachycardia syndrome as suspected adverse effects of vaccination against human papilloma virus.

Louise S. Brinth, Kirsten Pors, Ann C. Theibel, Jesper Mehlsen.

Vaccine, 2015, 33, 22, 2602-2605

http://www.sciencedirect.com/science/article/pii/S0264410X15004375

28.

Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature.

Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, Emilio Clementi.

Immunol Res. 2016

http://link.springer.com/article/10.1007/s12026-016-8820-z

29. 

Vaccinations and secondary immune thrombocytopenia with antiphospholipid antibodies by human papillomavirus vaccine.

 Mojca Bizjak , Or Bruck , Darja Kanduc , Sonja Praprotnik , Yehuda Shoenfeld.

Seminars in Hematology.

Volume 53, Supplement 1, 2016, S48–S50

http://www.sciencedirect.com/science/article/pii/S0037196316300269

30.

Pancreatitis after human papillomavirus vaccination: a matter of molecular mimicry.

Mojca Bizjak, Or Bruck, Sonja Praprotnik, Shani Dahan, Yehuda Shoenfeld.

Immunol Res. 2016.

http://link.springer.com/article/10.1007%2Fs12026-016-8823-9

31.

Pancreatitis following human  papillomavirus vaccination.

Amitabha Das, David Chang,  Andrew V Biankin and Neil D Merrett.

Medical Journal of Australia. 189, 3, 2008

https://www.mja.com.au/system/files/issues/189_03_040808/letters_040808_fm.pdf

32.

Development of unilateral cervical and supraclavicular lymphadenopathy after human papilloma virus vaccination.

Studdiford J, Lamb K, Horvath K, Altshuler M, Stonehouse A.

Pharmacotherapy. 2008, 28(9),1194-7

http://www.ncbi.nlm.nih.gov/pubmed/?term=18752390

33.

The quadrivalent human papillomavirus vaccine: erythema multiforme and cutaneous side effects after administration.

Pérez-Carmona L, Aguayo-Leiva I, González-García C, Jaén-Olasolo P.

Dermatology. 2010, 221(3),197-200

http://www.ncbi.nlm.nih.gov/pubmed/?term=20861606

34.

Erythema multiforme following vaccination for human papillomavirus.

Katoulis AC, Liakou A, Bozi E, Theodorakis M, Alevizou A, Zafeiraki A, Mistidou M, Stavrianeas NG.

Dermatology. 2010, 220(1), 60-2

http://www.ncbi.nlm.nih.gov/pubmed/?term=19887766

35.

Systemic lupus erythematosus following HPV immunization or infection?

Soldevilla HF, Briones SF, Navarra SV.

Lupus. 2012, 21(2), 158-61

http://www.ncbi.nlm.nih.gov/pubmed/?term=22235047

36.

Postural tachycardia syndrome (POTS) with anti-NMDA receptor antibodies after human papillomavirus vaccination.

Svetlana Blitshteyn Jill Brook.

Immunol Res. 2016

https://www.ncbi.nlm.nih.gov/pubmed/27561785

37.

Small Fiber Neuropathy Following Vaccination.

Kafaie,Jafar, Kim Minsoo, Krause Erik.

J Clin Neuromuscul Dis. 2016, 18(1), 37-40

https://www.ncbi.nlm.nih.gov/pubmed/27552388

38.

Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine. Sawai T, Shimizu M, Sakai T, Yachie A. J Pediatr Ophthalmol Strabismus. 2016, 53(3), 190

http://www.healio.com/ophthalmology/journals/jpos/2016-5-53-3/%7B84dc4f25-ff6c-4ec6-9f8e-9fee119712fd%7D/tubulointerstitial-nephritis-and-uveitis-syndrome-associated-with-human-papillomavirus-vaccine#

39.

 Human papilloma virus vaccination and dysautonomia: Considerations for autoantibody evaluation and HLA typing.

Hendrickson JE, Tormey CA.

Vaccine. 2016, 34(38), 4468

http://www.sciencedirect.com/science/article/pii/S0264410X1630319X .

40.

 EARLY CERVICAL MYELITIS AFTER HUMAN PAPILLOMA VIRUS VACCINATION.

Mireya Fernández-Fournier, Díaz de Terán, Antonio Tallón Barranco, Inmaculada Puertas.

Neurol Neuroimmunol Neuroinflamm. 2015, 2(1), e64.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303480/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204223/

41.

 Fibromyalgia-Like Illness in 2 Girls After Human Papillomavirus Vaccination.

Martínez-Lavín M.

J Clin Rheumatol. 2014, 20(7), 392.

http://journals.lww.com/jclinrheum/Citation/2014/10000/Fibromyalgia_Like_Illness_in_2_Girls_After_Human.12.aspx

42.

 Can HPV immunisation cause ADEM? Two case reports and literature review.

Pellegrino P, Carnovale C, Perrone V, Antoniazzi S, Pozzi M, Clementi E, Radice S.

Mult Scler. 2014, 20(6), 762.

http://journals.sagepub.com/doi/full/10.1177/1352458513502114

43.

 Human Papilloma Virus Vaccine Associated Uveitis

Holt HD, Hinkle DM, Falk NS, Fraunfelder FT, Fraunfelder FW.

Curr Drug Saf. 2014, 9(1), 65.

https://www.ncbi.nlm.nih.gov/pubmed/24191906 .

44.

 AUTOIMMUNE NEUROMYOTONIA FOLLOWING HUMAN PAPILLOMA VIRUS VACCINATION

Chiara Cerami MD, Massimo Corbo MD, Giovanni Piccolo MD, Sandro Iannaccone MD. Muscle & Nerve. 2013, 47(3), 466.

http://onlinelibrary.wiley.com/wol1/doi/10.1002/mus.23648/full .

45.

 Kikuchi–Fujimoto disease following vaccination against human papilloma virus infection and Japanese encephalitis.

Toru Watanabe, Hideki Hashidate, Yutaka Hirayama, Yasushi Iinuma.

European Journal of Pediatrics. 2012, 171(9), 1409.

http://link.springer.com/article/10.1007%2Fs00431-012-1729-1 .

46.

 Neuromyelitis optica following human papilloma virus vaccination.

Menge T, Cree B, Saleh A, Waterboer T, Berthele A, Kalluri SR, Hemmer B, Aktas O, Hartung HP, Methner A, Kieseier BC.

Neurology. 2012, 79(3), 285

http://www.neurology.org/content/79/3/285 .

47

. Linear IgA bullous dermatosis following human papillomavirus vaccination.

Ikeya S, Urano S, Tokura Y.

Eur J Dermatol. 2012, 22(6), 787

http://www.jle.com/fr/revues/ejd/e-docs/linear_iga_bullous_dermatosis_following_human_papillomavirus_vaccination_295060/article.phtml

48.

 Ampiginous choroiditis following quadrivalent human papilloma virus vaccine.

Khalifa YM, Monahan PM, Acharya NR.

Br J Ophthalmol. 2010, 94(1), 137.

http://bjo.bmj.com/content/94/1/137 .

49.

 Quadrivalent Human Papillomavirus recombinant vaccine associated lipoatrophy.

Ojaimi S, Buttery JP, Korman TM.

Vaccine. 2009, 27(36), 4876.

https://www.ncbi.nlm.nih.gov/pubmed/19555713 .

50.

 Multiple Evanescent White Dot Syndrome After Vaccination for Human Papilloma Virus and Meningococcus.

Cohen SM.

J Pediatr Ophthalmol Strabismus. 2009.

http://www.healio.com/ophthalmology/journals/jpos/2011-11-48-6/%7B9e038500-fa4f-47c0-8085-d80aeb659f8c%7D/multiple-evanescent-white-dot-syndrome-after-vaccination-for-human-papilloma-virus-and-meningococcus .

51.

 Opsoclonus myoclonus after human papilloma virus vaccine in a pediatric patient.

McCarthy JE, Filiano J.

Parkinsonism Relat Disord. 2009, 15(10), 792.

http://www.prd-journal.com/article/S1353-8020(09)00089-3/abstract .

52.

 Brachial plexus neuritis following HPV vaccination.

Debeer P, De Munter P, Bruyninckx F, Devlieger R.

Vaccine. 2008, 26(35), 4417.

http://www.sciencedirect.com/science/article/pii/S0264410X08008189 .

53.

Panuveitis With Exudative Retinal Detachments After Vaccination Against Human Papilloma Virus.

Dansingani KK, Suzuki M, Naysan J, Samson CM, Spaide RF, Fisher YL.

Ophthalmic Surg Lasers Imaging Retina. 2015, 46(9), 967.

https://www.ncbi.nlm.nih.gov/pubmed/26469238 .

54.

Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus.

Kenji Sekiguchi, Naoko Yasui, Hisatomo Kowa, Fumio Kanda, Tatsushi Toda.

Intern Med. 2016, 55(21), 3181.

https://www.ncbi.nlm.nih.gov/pubmed/27803416 .

55.

Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl. Hikiami R, Yamakado H, Tatsumi S, Ayaki T, Hashi Y, Yamashita H, Sawamoto N, Tsuji T, Urushitani M, Takahashi R. Intern Med.

Intern Med. 2018.

https://www.ncbi.nlm.nih.gov/pubmed/29434138


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